If you haven’t yet you should make some time to read Building Twitter Bootstrap at A List Apart. Especially if you’re interested in building a WordPress Theme Framework or WordPress Starter Theme.
It also reminds me a lot of the advice I’ve been giving people lately on using Theme Frameworks, Starter Themes, and Child Themes. Eventually I wind up saying the same thing over and over again: You should be building your own WordPress Theme Framework. Take the WordPress Default Theme, take an existing WordPress Theme Framework, or a Starter Theme, or any old theme that works, and make it your own. Iterate on it, build on it, refine it. Use it as Parent Theme or a Starter Theme. Make it your own. When you’re done you’ll have the best WordPress Theme — for you. And really that’s what you really want in the end.
But back to Building Twitter Bootstrap. If you’re interested in building your own WordPress Theme Framework there is some great advice in that article. Check out the Twitter Bootstrap project and think about building your own Theme Framework, Parent Theme, or Starter Theme.